Sanjeev Kumar*, N.K. Prasad, Kumari Shachi
Present study was aimed to evaluate the anti-diabetic efficacy of Ficus glomerata in Alloxan monohydrate induced in the albino rats. Oral administration of fresh Ficus glomerata leaves (2-4 g/day) for 60 days shows significant blood which is glucose lowering effect in experimental alloxan induced diabetic rats. These diabetic rats blood glucose level becamenormal when fed with Ficus glomerata leaves. It is amply revealed that fresh Ficus glomerata indica leaves possessed anti-diabetic properties. The results suggest that statistically significant anti-diabetic potential in alloxan monohydrate induced diabetic rats. The Ficus glomerata leaves to be almost similar effect like insulin treat ment in alloxan monohydrate administered animal model. From the present investigation it appeared that Ficus glomerata leaves might have some ingredients to increase the output of insulin by binding to the receptors of the Beta cells of the Langerhans loca ted in the pancreas. Once they bind to the Sulphonyl urea receptors, the channels are probably closed and therefore the membrane is depolarized and insulin production is stimulated.