Badaruddoza, Basanti Barna, Kawaljit Matharoo and Bhanwer AJS
In many worldwide populations, the K121Q variant of ENPP1 gene are associated with increased risk of type 2 diabetes mellitus (T2DM). The objective of the present study was to investigate the association of K121Q variant of ENPP1 gene with T2DM in North Indian Punjabi populations. A total of 500 participants consisting 250 T2DM patients and 250 healthy unrelated subjects were recruited for this study. The PCR-RFLP method was used for genotyping of K121Q polymorphism. The minor allele Q was found to be significantly associated with increased risk of T2DM (OR: 1.44, 95% CI: 1.06-1.94, p=0.015). A significant difference in QQ genotype was observed between T2DM patients and control groups (OR: 2.04, 95% CI: 1.04-3.98, p=0.033). It is also observed that co-dominant model would be best fit to predict the susceptible gene effect (OR: 1.36, 95% CI: 1.04-1.80, p=0.026). This study confirmed the association of ENPP1 polymorphism with increased risk of T2DM.