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article de recherche

Disruption of Nrf2 Synergizes with High Glucose to Cause Heightened Myocardial Oxidative Stress and Severe Cardiomyopathy in Diabetic Mice

Xiaoqing He and Qiang Ma

High glucose-induced oxidative stress is a major contributing mechanism to the development of diabetic cardiomyopathy. Nrf2 is an emerging critical regulator of cellular defense..Voir plus»

Rapport de cas

Multicentric Reticulohistiocytosis: A Reason for Erosive Arthritis

Yuan Yao, Jinjun Wang, Bin Liu, Xuan Zhang and Stanley M Naguwa

Multicentric Reticulohistiocytosis (MRH) is a rare histiocytic disorder that primarily involves the skin and joints but can affect multiple visceral organs. A female patient pre..Voir plus»

Article de révision

Family Skills Training Intervention for ADHD: Putting the Child Back into Child Therapy

David F Curtis, Corey L Heath, Stephanie G Chapman and

Attention-Deficit/Hyperactivity Disorder (ADHD) affects over 7% of school-aged children in the US, and it is the most common reason pediatricians refer children for psychosocial..Voir plus»

article de recherche

Dysglycemia and Dyslipidemia Models in Nonhuman Primates: Part V. Diabetic Nephropathy and Effects of Angiotensin Ⅱ Receptor Antagonist Losartan

Jiajun Gao, Xiaoli Wang, Weihua Song, Yixin (Jim) Wang, Yong-Fu Xiao

Long-term hyperglycemia can impair renal microvessels and lead to diabetic nephropathy (DN). Early treatment can delay or prevent its progression. Efficacy of monoclonal antibod..Voir plus»

article de recherche

Dynamic Changes of Betatrophin and Its Potential Effect on β-cells in Spontaneously Developed or Streptozocin-induced Diabetes Monkeys

Yongqiang Liu, Xiaoli Wang, Bingdi Wang, Guofeng Sun, Francine Gregoire, Keefe Chng, Jinhu Wang, Yixin (Jim) Wang and Yong-Fu Xiao

Effects of betatrophin on β-cell proliferation and insulin secretion have been reported controversially in rodent studies. This study was to investigate the dynamic changes..Voir plus»

Commentaire

On Evaluation of Rankings in Analysis of NGS Data

Donald MR, Wilson SR

A ranked list of genes (or proteins or regions) is a common output from analysis of NGS data. Many choices will have been made in the analysis (either explicitly or implicitly) ..Voir plus»