The autoimmune response to AGE-modified human DNA and its implications for type 1 diabetic mellitus

Musraf Uddin

Aims: Both in vivo and in vitro non-enzymatic glycation of DNA produces free radicals, or glycoxidation. Neo-antigenic epitopes, which play a role in auto..Voir plus»

Leptadenia pyrotechnica Induces P53-Dependent Apoptosis in Colon Cancer Cells

Mohammad A Khasawneh, Adrian Koch, Hanan M Elwy, Alaaeldin A Hamza and Regine Schneider- Stock

Leptadenia pyrotechnica has been commonly used traditionally for the treatment of tumors in Gulf countries. However, the molecular mechanism of the anti-cancer ..Voir plus»

Elevated Angiotensin II in Rat Nodose Ganglia Primes Diabetes-Blunted Arterial Baroreflex Sensitivity: Involvement of NADPH Oxidase Derived Superoxide

Yu-Long Li

Clinical trials and experimental animal studies have confirmed the contribution of arterial baroreflex impairment in causing excess morbidity and mortality in type-1 diabetes. ..Voir plus»

Note to Readers

Masayoshi Yamaguchi

Journal of General Medicine is a high-quality peer reviewed journal with a frequency of monthly issue release, containing several high quality and unique articles. It publishes ..Voir plus»

Insulin Glargine versus Insulin Detemir: Glycemic Control and Insulin Dose in Type 2 Diabetes Mellitus Patients Using a Medical Record Linkage System in the Netherlands

Ingo A Eland, Edith M. Heintjes, Leanne Houweling, Ricardo deGrooth, Thiemo F. Veneman and K. Paul Bouter

Background: In randomized controlled trials, patients with type 2 diabetes mellitus required higher doses of insulin detemir than insulin glargine to obtain the..Voir plus»

Palpable Radial Pulse Despite Artery Occlusion - How is that Possible? A Localized Livedo Racemosa Leads to the Solution

This case report highlights the diagnostic value of livedo racemosa as a clinical clue for radial artery occlusion. Increasing use of radial atrial cannulation in clinical routi..Voir plus»